External Validity of the HOPE-Trial
نویسندگان
چکیده
منابع مشابه
Weighting for External Validity∗
External validity is a challenge in treatment effect estimation. Even in randomized trials, the experimental sample often differs from the population of interest. If participation decisions are explained by observed variables such differences can be overcome by reweighting. However, participation may depend on unobserved variables. Even in such cases, under a common support assumption there exi...
متن کاملTheory and External Validity
Winer (1999 [this issue]) proposes that external validity concerns require more attention in theoretical research. The author argues that one cannot “enhance” external validity by choosing one method over another. External validity can only be “assessed” by better understanding how the focal variables in one’s theory interact with moderator variables that are seen as irrelevant early in a resea...
متن کاملA literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results
Randomized controlled trials (RCTs) are conducted under idealized and rigorously controlled conditions that may compromise their external validity. A literature review was conducted of published English language articles that reported the findings of studies assessing external validity by a comparison of the patient sample included in RCTs reporting on pharmaceutical interventions with patients...
متن کاملExternal validity of a randomised controlled trial on the treatment of severe infections caused by MRSA
OBJECTIVES To assess the external validity of a pragmatic, investigator-initiated RCT on treatment of severe infections caused by methicillin-resistant Staphylococcus aureus (MRSA), we compared patient characteristics and treatment effect estimates for patients included in the RCT versus those excluded. PARTICIPANTS AND OUTCOMES The RCT included hospitalised patients with documented or highly...
متن کاملExternal, Internal and Construct Validity
Introduction In research, validity refers to the degree to which findings are applicable in real-life situations. Essentially, if the findings are strongly valid, it implies that they have an excellent degree of applicability. In contrast, low validity implies that the survey is not applicable in real-life situations. The specific approach used during research has strong influence on validity. ...
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ژورنال
عنوان ژورنال: JBJS Open Access
سال: 2019
ISSN: 2472-7245
DOI: 10.2106/jbjs.oa.18.00061